For Healthcare Providers

Managing common side effects of ALECENSA® (alectinib)

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What can I do about common side effects?

Your care team is the best resource for any questions you may have. In addition, we’ve provided guidance for some side effects that may occur while taking ALECENSA. Open communication with your care team is key for a successful treatment experience.

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What should I do if I'm concerned about liver problems?

Your doctor may have told you that liver problems are common with treatment or you may have had your liver tests come back already. Changing lifestyle habits may help improve liver health. Here are some suggestions:

  • Limit alcohol consumption
  • Eat fruits, vegetables, and whole grains
  • Limit foods with sugar or fructose
  • Eat healthier fats, such as olive oil and walnuts. Limit red meat
  • Maintain a healthy weight
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Should I avoid being in the sunlight while taking ALECENSA?

  • You may burn more easily and get severe sunburns, so avoid spending time in the sunlight during treatment with ALECENSA and for 7 days after the final dose of ALECENSA
  • Use sunscreen and lip balm with SPF 50 or greater to help protect against sunburn 
  • Wear a long-sleeved shirt, long pants and/or skirts, and a wide-brimmed hat to help protect your skin from UV rays
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How can I combat my tiredness or fatigue?

  • Talk to your doctor about how to stay active
  • Practice mind-body strategies, like meditation
  • Work with a physical therapist
  • Talk with a counselor
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How should I deal with constipation?

  • Drink more liquids; water is best
  • Eat more fiber like whole grains, vegetables, fruit, and nuts
  • Increase your physical activity 
  • Talk to your doctor about fiber supplements or laxatives
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What if I get swelling in my hands, feet, ankles, face, or eyelids (edema)?

  • Limit salt in your diet 
  • Ask your doctor for specific exercises to help with circulation
  • Raise your feet when resting 
  • Wear loose clothing around swollen areas 
  • Wear compression socks, sleeves, or gloves that help with circulation and may help with severe swelling 
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What can I do if I have muscle pain, tenderness, or weakness (myalgia)?

  • Get a massage or physical therapy 
  • Do light exercise 
  • Apply heat or cold 
  • Try relaxation techniques; sometimes even a few deep breaths can help 
  • Talk to your doctor about medications to treat muscle aches and reduce the pain 
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Is there something I can do if I have a low red blood cell count (anemia)?

  • Eat foods that are good sources of iron 
  • Talk to your doctor about treatment options like medication or supplements 

It’s important to talk to your doctor before taking any action to minimize side effects

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What should you tell your doctor before starting ALECENSA?

Find out more
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See Important Safety Information

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Important Safety Information & Indications

Who is ALECENSA for?

ALECENSA is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene:

  • To help prevent your lung cancer from coming back after your tumor has been removed by surgery (adjuvant), or 
  • As treatment if your lung cancer has spread to other parts of the body (metastatic)

Your doctor will perform a test to make sure that ALECENSA is right for you. It is not known if ALECENSA is safe and effective in children.

What is the most important information I should know about ALECENSA?

Everyone reacts differently to treatment with ALECENSA. It’s important to know the most serious and most common side effects with ALECENSA.

Your doctor may lower the dose or stop treatment with ALECENSA if any side effects occur. Contact your doctor right away if you have any of the following side effects.

ALECENSA may cause serious side effects, including:

Liver problems (hepatotoxicity). Liver problems are common with ALECENSA and can be severe. Your doctor will do blood tests at least every 2 weeks for the first 3 months, and then 1 time each month and as needed during treatment with ALECENSA to check your liver function. Tell your doctor right away if you get any of the following signs and symptoms:

  • Feeling tired
  • Feeling less hungry than usual
  • Yellowing of your skin or the whites of your eyes
  • Dark urine
  • Itchy skin
  • Nausea or vomiting
  • Pain on the right side of your stomach area
  • Bleeding or bruising more easily than normal 

Lung problems. ALECENSA may cause severe or life-threatening swelling (inflammation) of the lungs during treatment. Symptoms may be similar to those symptoms from lung cancer. Tell your doctor right away if you have any new or worsening symptoms, including trouble breathing, shortness of breath, cough, or fever.

Kidney problems. ALECENSA may cause severe kidney problems that can lead to death. Tell your doctor right away if you have a change in the amount or color of your urine, or if you get new or worsening swelling in your legs or feet.

Slow heartbeat (bradycardia). ALECENSA may cause very slow heartbeats that can be severe. Your doctor will check your heart rate and blood pressure during treatment with ALECENSA. Tell your doctor right away if you feel dizzy, lightheaded, or if you faint during treatment with ALECENSA. Tell your doctor if you take any heart or blood pressure medicines.

Severe muscle pain, tenderness, and weakness (myalgia). Muscle problems are common with ALECENSA and can be severe. Your doctor will do blood tests at least every 2 weeks for the first month and as needed during treatment with ALECENSA. Tell your doctor right away if you have any new or worsening signs and symptoms of muscle problems, including unexplained muscle pain or muscle pain that does not go away, tenderness, or weakness.

Breakdown of healthy red blood cells earlier than normal (hemolytic anemia). Hemolytic anemia can happen in some people who take ALECENSA. If this happens, you may not have enough healthy red blood cells. Your doctor may temporarily stop ALECENSA and do blood tests, if needed, to check for this problem. If you develop hemolytic anemia, your doctor may either restart you on ALECENSA at a lower dose when the hemolytic anemia goes away, or may stop your treatment with ALECENSA. Tell your doctor right away if you experience yellow skin (jaundice), weakness or dizziness, or shortness of breath.

What should I tell my doctor before taking ALECENSA?

Before you take ALECENSA, tell your doctor about all of your medical conditions, including if you:

  • Have liver problems
  • Have lung or breathing problems
  • Have a slow heartbeat
  • Are pregnant or plan to become pregnant. ALECENSA can harm your unborn baby.
    Females who are able to become pregnant:
    • Your doctor will do a test to see if you are pregnant before starting treatment with ALECENSA
    • You should use effective birth control (contraception) during treatment with ALECENSA and for 5 weeks after the last dose of ALECENSA
    • Tell your doctor right away if you become pregnant during treatment with ALECENSA or think you may be pregnant
    Males who have female partners that are able to become pregnant should use effective birth control (contraception) during treatment with ALECENSA and for 3 months after the last dose of ALECENSA
  • Are breastfeeding or plan to breastfeed. It is not known if ALECENSA passes into your breast milk. Do not breastfeed during treatment with ALECENSA and for 1 week after the last dose of ALECENSA. Talk to your doctor about the best way to feed your baby during this time

Tell your doctor about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

What should I avoid while taking ALECENSA?

Avoid spending time in the sunlight during treatment with ALECENSA and for 7 days after the final dose of ALECENSA. Your skin may be sensitive to the sun (photosensitivity) and you may burn more easily and get severe sunburns. Use sun protecting measures, such as sunscreen and lip balm with SPF 50 or greater to help protect against sunburn.

What are the possible side effects of ALECENSA?

The most common side effects of ALECENSA include:

  • constipation
  • tiredness
  • swelling in your hands, feet, ankles, face, and eyelids
  • rash
  • cough

These are not all of the possible side effects of ALECENSA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

Please see additional Important Safety Information in full Prescribing Information, including Patient Information.